Shiitake Extract Used in Asia as Cancer Medication
Tell Americans that a dish contains "mushrooms" and their minds automatically jump to button mushrooms (Agaricus bisporus), which have been grown commercially in the West since the 1600's. In contrast, individuals from Far East Asia are far more likely to jump to Shiitake as the most logical ingredient. Shiitake, which has only recently become a common household name in the West, has a long history of commercial cultivation in Asia.
Originating in China, wild Shiitake is also commonly known as Black Mushroom and Chinese Mushroom. The name Shiitake comes from the Chinese Shii Tree, which is the most common host tree. But it can also grow on beeches and oaks. The cultivation of Shiitake in China and Japan goes back at least 1000 years.
What is less known in the West is that in the form of Shiitake extract, this is also the most studied medicinal mushroom of the Orient. The primary focus of research has been on the anti-viral [93] and anti-tumoral [94] properties.
The preferred part of Shiitake to use medicinally is the mycelium (the "roots") because they contain compounds that either don't exist in the fruit body ("mushroom"), or are much more concentrated in the mycelium.
The most common extract is known as LEM, a protein extract from Lentinula Edodes Mycelia. (Lentinula edodes is Latin for Shiitake.) LEM has been shown to have powerful immune boosting properties, [95, 96, 97] particularly anti-bacterial. [98, 99] LEM has also been found to exhibit anti-cancer properties. [100] One study found it to kill melanoma cells while causing no harm to healthy cells. [101]
Another active compound of Shiitake extract that has been much studied is Lentinan; a protein-free polysaccharide, so named after Lentinula, the Latin genus name for Shiitake. Lentinan does not directly kill tumors but has been shown to stimulate the tumor fighting mechanisms in the body of test subjects, [102, 103, 104, 105, 106, 107, 108, 109, 110] and is in fact in use in Asia as an injected cancer medication.
Arabinoxylanes, compounds resulting from Shiitake-on-rice fermentation, have also demonstrated significant anti-viral activity. [111, 112, 113]
Two viruses in particular that have been studied with promising results are herpes simplex type 1 [114] and HIV [115, 116, 117]. It should be mentioned, however, that the previously mentioned Lentinan as an isolated compound does not appear to affect HIV replication. [25]
Additional studies have reported positive results with Shiitake extract in conditions of chronic fatigue syndrome [119] and Candida [118], as well as for septic shock prevention. [120]
And last but not least, in his book Mycelium Running, foremost U.S. medicinal mushroom expert Paul Stamets also lists the following areas where Shiitake has been reported as having a therapeutic effect: Blood sugar; blood pressure; kidney support; cholesterol; liver health; stress; sexual dysfunction; breast cancer; prostate cancer; liver cancer. [134]
Note: The statements on this page have not been evaluated by the Food and Drug Administration. This article is not intended to diagnose, treat, cure or prevent any disease. Never use any medicinal mushroom or herb without prior approval by medical doctor.
Credits: Thank you, Paul Stamets, for research references. - 17268
Originating in China, wild Shiitake is also commonly known as Black Mushroom and Chinese Mushroom. The name Shiitake comes from the Chinese Shii Tree, which is the most common host tree. But it can also grow on beeches and oaks. The cultivation of Shiitake in China and Japan goes back at least 1000 years.
What is less known in the West is that in the form of Shiitake extract, this is also the most studied medicinal mushroom of the Orient. The primary focus of research has been on the anti-viral [93] and anti-tumoral [94] properties.
The preferred part of Shiitake to use medicinally is the mycelium (the "roots") because they contain compounds that either don't exist in the fruit body ("mushroom"), or are much more concentrated in the mycelium.
The most common extract is known as LEM, a protein extract from Lentinula Edodes Mycelia. (Lentinula edodes is Latin for Shiitake.) LEM has been shown to have powerful immune boosting properties, [95, 96, 97] particularly anti-bacterial. [98, 99] LEM has also been found to exhibit anti-cancer properties. [100] One study found it to kill melanoma cells while causing no harm to healthy cells. [101]
Another active compound of Shiitake extract that has been much studied is Lentinan; a protein-free polysaccharide, so named after Lentinula, the Latin genus name for Shiitake. Lentinan does not directly kill tumors but has been shown to stimulate the tumor fighting mechanisms in the body of test subjects, [102, 103, 104, 105, 106, 107, 108, 109, 110] and is in fact in use in Asia as an injected cancer medication.
Arabinoxylanes, compounds resulting from Shiitake-on-rice fermentation, have also demonstrated significant anti-viral activity. [111, 112, 113]
Two viruses in particular that have been studied with promising results are herpes simplex type 1 [114] and HIV [115, 116, 117]. It should be mentioned, however, that the previously mentioned Lentinan as an isolated compound does not appear to affect HIV replication. [25]
Additional studies have reported positive results with Shiitake extract in conditions of chronic fatigue syndrome [119] and Candida [118], as well as for septic shock prevention. [120]
And last but not least, in his book Mycelium Running, foremost U.S. medicinal mushroom expert Paul Stamets also lists the following areas where Shiitake has been reported as having a therapeutic effect: Blood sugar; blood pressure; kidney support; cholesterol; liver health; stress; sexual dysfunction; breast cancer; prostate cancer; liver cancer. [134]
Note: The statements on this page have not been evaluated by the Food and Drug Administration. This article is not intended to diagnose, treat, cure or prevent any disease. Never use any medicinal mushroom or herb without prior approval by medical doctor.
Credits: Thank you, Paul Stamets, for research references. - 17268
About the Author:
Dr. Markho Rafael has devoted his life to natural health since finishing Chiropractic College in 1996. He currently specializes in to research and write about medicinal mushrooms, including extract of Shiitake. For research references to this article, go to the Shiitake mushroom extract page and click on any number indicating a reference.
posted by X - Men at
6:44 AM
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